Transplant Biomarker Publications

Development and Clinical validity of a novel blood-based molecular biomarker for sub-clinical acute rejection following kidney transplant

American Journal of Transplantation  First published: 09 July 2018  https://doi.org/10.1111/ajt.15011

John J. Friedewald1, Sunil M. Kurian, Raymond L. Heilman, Thomas C. Whisenant, EmilioD. Poggio, Christopher Marsh, Prabhakar Baliga MD, Jonah Odim, Merideth M. Brown, David N. Ikle, Brian D. Armstrong, jane I. charette, Susan S. Brietigam, Nedjema Sustento-Reodica, Lihui Zhao, Manoj Kandpal, Daniel R. Salomon†, and Michael M. Abecassis*(ORCID 0000-0001-9333-463X), for the Clinical Trials in Organ Transplantation08 (CTOT-08)

Value of the TruGraf Blood Test as a Biomarker for Monitoring Renal Transplant Recipients

Insights in Biomedicine April 2017  Vol.3 No. 2:8 ISSN 2572-5610

First MR, Rose S, Schieve C, Lee D, Lewis P, Pierry D, David J, McNulty M, Clark D, Weiss G, Kurian S Whisenant T, Friedewald JJ and Abecassis MM

Clinical Utility of Peripheral Blood Gene Expression Profiling of Kidney Transplant Recipients to Assess the Need for Surveillance Biopsies in Subjects with Stable Renal Function

J. Transplant Technol Res, Nov 10-2017, Vol 7(3): 177

Martin Roy First, Thomas Whisenant, John J Friedewald, Peter Lewis, Stan Rose, Darren Lee, Deirdre Pierry, Sunil M Kurian, Terri Gelbart and Michael M Abecassis

Biomarker Guidelines for High-Dimensional Genomic Studies in Transplantation: Adding Method to the Madness

Transplantation March 2017 Volume 101, Number 3

Sunil M. Kurian, PhD, Thomas Whisenant, PhD, Valeria Mas, PhD, Raymond Heilman, MD, Michael Abecassis, MD, Daniel R. Salomon, MD, Adyr Moss, MD and Bruce Kaplan, MD

Orthogonal Comparison of Molecular Signatures of Kidney Transplants With Subclinical and Clinical Acute Rejection: Equivalent Performance Is Agnostic to Both Technology and Platform

American Journal of Transplantation Jan. 2017; 17: 2103 – 2116
S. M. Kurian, E. Velazquez, R. Thompson, T. Whisenant, S. Rose, N. Riley, F. Harrison, T. Gelbart, and J. J. Friedewald, J. Charette, S. Brietigam, J. Peysakhovich, M. R. First, M. M. Abecassis and D. R. Salomon

Genomic Biomarkers Correlate with HLA-Identical Renal Transplant Tolerance

J Am Soc Nephrol 2013;24(9):1376-1385

Leventhal JR, Mathew JM, Salomon DR, Kurian SM, Suthanthiran M, Tambur A, Friedewald J, Gallon L, Charette J, Levitsky J, Kanwar Y, Abecassis M, Miller J

Genomic meta-analysis of growth factor and integrin pathways in chronic kidney transplant injury

BMC Genomics 2013;14:275

Dosanjh A, Robison E, Mondala T, Head SR, Salomon DR, Kurian SM

The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys

Proc Natl Acad Sci U S A 2012;109(16): 6036-6041

Grover RK, Cheng J, Peng Y, Jones TM, Ruiz DI, Ulevitch RJ, Glass JI, Dennis EA, Salomon DR, Lerner RA

Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal

Proc Natl Acad Sci U S A 2011;108(14):5560-5565

Cheng J, Torkamani A, Grover RK, Jones TM, Ruiz DI, Schork NJ, Quigley MM, Hall FW, Salomon DR, Lerner RA

Molecular mechanisms of chronic kidney transplant rejection via large-scale proteogenomic analysis of tissue biopsies

J Am Soc Nephrol 2010;21(2):362-373

Nakorchevsky A, Hewel JA, Kurian SM, Mondala TS, Campbell D, Head SR, Marsh CL, Yates JR III, Salomon DR

Biomarkers for early and late stage chronic allograft nephropathy by proteogenomic profiling of peripheral blood

PLoS One 2009;4(7):e6212

Kurian SM, Heilman R, Mondala TS, Nakorchevsky A, Hewel JA, Campbell D, Robison EH, Wang L, Lin W, Gaber L, Solez K, Shidban H, Mendez R, Schaffer RL, Fisher JS, Flechner SM, Head SR, Horvath S, Yates JR III, Marsh CL, Salomon DR

Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs

Transplantation 2007;83(7):883-892

Flechner SM, Goldfarb D, Solez K, Modlin CS, Mastroianni B, Savas K, Babineau D, Kurian S, Salomon D, Novick AC, Cook DJ

Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes

Am J Transplant 2004;4(9):1475-1489

Flechner SM, Kurian SM, Head SR, Sharp SM, Whisenant TC, Zhang J, Chismar JD, Horvath S, Mondala T, Gilmartin T, Cook DJ, Kay SA, Walker JR, Salomon DR

De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years

Am J Transplant 2004;4(11):1776-1785

Flechner SM, Kurian SM, Solez K, Cook DJ, Burke JT, Rollin H, Hammond JA, Whisenant T, Lanigan CM, Head SR, Salomon DR

Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate with Worse Long-Term Outcomes

Am J Transplant 2016; XX: 1-17

B. D. Modena, S. M. Kurian SM, L. W. Gaber,  J. Waalen, A. I. Su, T. Gelbart, T.S. Mondala, S. R. Head, S. Papp, R. Heilman, J. J. Friedewald, S. M. Flechner, C.L. Marsh, R.S. Sung, H. Shidban, L. Chan, M. M. Abecassis, D. R. Salomon

Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate with Worse Long-Term Outcomes

Am J Transplant 2016; XX: 1-17

B. D. Modena, S. M. Kurian SM, L. W. Gaber,  J. Waalen, A. I. Su, T. Gelbart, T.S. Mondala, S. R. Head, S. Papp, R. Heilman, J. J. Friedewald, S. M. Flechner, C.L. Marsh, R.S. Sung, H. Shidban, L. Chan, M. M. Abecassis, D. R. Salomon

Biomarker Guidelines for High-Dimensional Genomic Studies in Transplantation: Adding Method to the Madness

Transplantation 03-2017; 101(03):457-463

Kurian SM, Whisenant T, Mas V, Heilman R, Abecassis MM, Salomon DR, Moss A, Kaplan B,

An Economic Analysis of the Cost Effectiveness of Blood Gene Expression Profiling in Kidney Transplant Recipients

Journal of Health & Medical Economics, July 2017 – ISSN 2471-9927.  Vol.3 No.1.3

Roy First M, Darren Lee, Peter Lewis and Stan Rose

 

Molecular Classifiers for Acute Kidney Transplant Rejection in Peripheral Blood by Whole Genome Gene Expression Profiling

Am J Transplant 2014; 5(14):1164-1172

Kurian SM, Williams AN, Gelbart T, Campbell D, Mondala TS, Head SR, Horvath S, Gaber L, Thompson R, Whisenant T, Lin W, Langfelder P, Robison EH, Schaffer RL, Fisher JS, Friedewald J, Flechner SM, Chan LK, Wiseman AC, Shdban H, Mendez R, Heilman R, Abecassis MM, March CL, Salomon DR

Analytical and Clinical Validation of a Molecular Diagnostic Signature in Kidney Transplant Recipients

Journal of Transplantation Technologies & Research, September – 2017, 7:3

Martin Roy First, Deirdre Pierry, Michael McNulty, Sunil M Kurian, Stan Rose, Thomas Whisenant, Terri Gelbart, April Venzon, Nadia Bayat, Peter Lewis, John J Friedewald, Michael M Abecassis and Darren Lee

An Economic Analysis of the Cost Effectiveness of Blood Gene Expression Profiling in Kidney Transplant Recipients

Journal of Health & Medical Economics, July – 2017, ISSN 2471-9927 vol.3, 1:3

Roy First M, Darren Lee, Peter Lewis and Stan Rose

Value of the TruGraf Blood Test as a Biomarker for Monitoring Renal Transplant Recipients

Insights in Biomedicine ISSN 2572-5610, April – 2018,  vol.3 No.2:8

First MR, Rose S, Schieve C, Lee D, Lewis P, Pierry D, David J, McNulty M, Clark D, Weiss G, Kurian S,  Whisenant T, Friedewald JJ and Abecassis MM 

Analytical and Clinical Validation of a Molecular Diagnostic Signature in Kidney Transplant Recipients

J Transplant Technology Research,  September 2017, 7:3

Martin Roy First, Deirdre Pierry, Michael McNulty, Sunil M Kurian, Stan Rose, Thomas Whisenant, Terri Gelbart, April Venzon, Nadia Bayat, Peter Lewis, John J Friedewald, Michael M Abecassis and Darren Lee

Clinical Utility of Peripheral Blood Gene Expression Profiling in Kidney Transplant Recipients to Assess the Need for Surveillance Biopsies in Subjects with Stable Renal Function

Journal of Transplant Technology & Research Research,  November 2017, 7:3

Martin Roy First, Thomas Whisenant, John J Friedewald, Stan Rose, Darren, Lee, Sunil Kurian, Dierdra Pierry, Peter Lewis, Terri Gelbart, Michael M Abecassis

Clinical Utility of Peripheral Blood Gene Expression Profiling in Kidney Transplant Recipients to Assess the Need for Surveillance Biopsies in Subjects with Stable Renal Function

Journal of Transplant Technology & Research Research,  November 2017, 7:3

Martin Roy First, Thomas Whisenant, John J Friedewald, Stan Rose, Darren, Lee, Sunil Kurian, Dierdra Pierry, Peter Lewis, Terri Gelbart, Michael M Abecassis

Biomarker Guidelines for High-Dimensional Genomic Studies in Transplantation: Adding Method to the Madness

Transplantation March 2017  Volume 101  Number 3

Sunil M. Kurian, PhD, Thomas Whisenant, PhD, Valeria Mas, PhD, Raymond Heilman, MD, Michael Abecassis, MD, Daniel R. Salomon, MD, Adyr Moss, MD, and Bruce Kaplan, MD

Biomarker Guidelines for High-Dimensional Genomic Studies in Transplantation: Adding Method to the Madness

Transplantation March 2017, Volume 101, Number 3 

Sunil M. Kurian, PhD, Thomas Whisenant, PhD, Valeria Mas, PhD, Raymond Heilman, MD, Michael Abecassis, MD, Daniel R. Salomon, MD, Adyr Moss, MD, and Bruce Kaplan, MD

Library Construction for Next-generation Sequencing: Overviews and Challenges

Biotechniques February 2014; 56:61-77

Head SR, Komori HK, LaMere SA, Whisenant T, Van Nieuwerburgh F, Salomon DR, Ordoukhanian P

An Economic Analysis of the Cost Effectiveness of Blood Gene Expression Profiling in Kidney Transplant Recipients

Journal of Health & Medical Economics ISSN 2471-9927, July 2017, vol.3 No.1:3

Roy First M, Darren Lee, Peter Lewis and Stan Rose

Advancing Transplantation In Silico: Studying Global Gene Expression Using Functional Genomics for Transplantation Research

Textbook of Organ Transplantation (pp. 208-218). Chichester, England: Wiley-Blackwell (2014)

Head SR, Kurian SM, Salomon DR